August 8 2013 – Aradigm Awarded NIH Grant to Investigate New Methods of Diagnoses of Aspirations of Gastrointestinal Contents into the Respiratory Tract with Scientists at UC San Francisco


The National Heart, Lung, and Blood Institute, National Institutes of  Health (NIH), awarded Aradigm Corporation (ARDM) a Small Business  Initiative Research (SBIR) grant to investigate the development and  validation of tests for gastro-esophageal reflux with aspirations into  the respiratory tract. The Principal Investigators and co-inventors of  the new diagnostic tests are Professor Homer Boushey, University of  California, San Francisco (UCSF) and Dr. Igor Gonda, Aradigm  Corporation. The grant of approximately $260,000 is funding laboratory  work and a human clinical trial to be conducted at UCSF.

Aspiration of gastric contents into the respiratory tract causes  significant morbidity and mortality and is accepted as the key  initiating event for aspiration pneumonitis – a form of acute lung  injury caused by the acidity of the gastric contents, and aspiration  pneumonia – the consequence of the growth of pathogenic bacteria  contained in the oropharynx aspirated into the tracheobronchial tree.  When subclinical events of gastric aspiration occur, it is described as   “silent aspiration” or “microaspiration.” Chronic, recurrent  microaspirations have been implicated in the pathogenesis and worsening  of many severe chronic pulmonary diseases of unknown origin, such  idiopathic pulmonary fibrosis, bronchiolitis obliterans after lung  transplantation, pulmonary disease in conditions associated with  esophageal dysfunction and delayed gastric emptying such as cystic  fibrosis and scleroderma, and the very common conditions of community  acquired pneumonia in the elderly, asthma and COPD.

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