December 12 2011 Stanford-researchers reveal how mechanical forces contribute to scarring

When you get a cut, fibrous connective tissue replaces normal skin, sometimes leaving a visible scar. This process is called fibrosis, and it’s a normal part of the healing process. But sometimes scar formation can be dangerous, disfiguring or just unsightly.

Now Stanford researchers have unraveled how mechanical force contributes to inflammation and scarring in mice, a finding that could potentially lead to new therapies for fibrotic diseases, such as pulmonary fibrosis, and inflammatory diseases, such as rheumatoid arthritis, in humans. Their findings were reported yesterday in Nature Medicine.

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