December 01 2013 – Human stem cells converted to functional lung cells

NEW YORK, NY

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November 30 2013 – Keyhole lung transplant performed on 60-year-old in Chennai

Surgeons at Global Health City have performed a minimally-invasive lung transplant on a 60-year-old patient, who has been suffering from idiopathic pulmonary fibrosis for the last 11 years.

The lung transplant was done through a seven-inch-long incision, which is nearly one-third the length used in the conventional procedure, doctors said.

Raja Babu Shah, an Indian-origin businessman residing in Nepal, had severe breathlessness and had required oxygen supply fulltime for the last four years. He was confined to his bed and a wheelchair.

In idiopathic pulmonary fibrosis, the cause for which is not known, the lung becomes stiff and does not expand well. There are poor oxygen levels in the blood, said Vijil Rahulan, head of the department, respiratory medicine and senior consultant pulmonologist, Global Health City.

Read the entire article at:

http://www.thehindu.com/news/cities/chennai/keyhole-lung-transplant-performed-on-60yearold-in-chennai/article5405805.ece

For more information about Idiopathic Pulmonary Fibrosis please visit our websitewww.ipftoday.com

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November 27 2013 – FibroGen Announces Observations of Possible Disease Stabilization and Improvement in Interim Analysis of Phase 2 Study of FG-3019

SAN FRANCISCO–(BUSINESS WIRE)–FibroGen, Inc. (FibroGen), announced today that interim results from an ongoing open-label Phase 2 clinical study to evaluate FG-3019 as a treatment for idiopathic pulmonary fibrosis (IPF) continue to suggest that the investigational drug has the potential to stabilize and improve fibrosis in patients with the disease. The results substantiate earlier results reported in an oral presentation at the European Respiratory Society Annual Congress in September 2012.

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November 15 2013 – Enzo Biochem Announces Study in Leading Scientific Journal Linking Idiopathic Pulmonary Fibrosis, a Deadly Human Disease with No Effective Treatment Options, to Presence of a Monkey Virus

Enzo Biochem Inc. (NYSE:ENZ) today announced publication of a study in a leading scientific journal Modern Pathology a Nature Publishing Group publication that shows a strong association of idiopathic pulmonary fibrosis (IPF) a pulmonary disease with 100% mortality within five years with the presence of the herpesvirus saimiri virus a virus native to squirrel monkeys. The breakthrough discovery of the IPF

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November 10 2013 – Research by Saint Louis University scientists offers way to disrupt fibrosis

ST. LOUIS

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November 4 2013 – Development Plan for PTL-202, a Treatment for Progressive Organ Scarring, a $1.1 Billion Opportunity

Worldwide, there are over 5,000,000 people living with Idiopathic Pulmonary Fibrosis (IPF)(IPF Coalition).IPF therapy sales across the US, France, Germany, Italy, Spain, and the UK to rise to over $1.1 billion by 2017, at a Compound Annual Growth Rate (CAGR) of 86.6% (RnR Market Research, 2013). IPF kills more patients per year than either prostate or breast cancer.

Pacific Therapeutics Ltd. (the “Company”) lead drug candidate for fibrosis (progressive scarring of the organ), PTL-202 is a combination of Pentoxifylline (a FDA approved drug used for treating leg cramps) and N-Acetyl-Cysteine (NAC) an amino acid and an extremely potent and important antioxidant.

As previously announced the company has completed a phase 1 trial of the combination in humans. The positive results from the phase 1 clinical trial and positive pre-clinical results, will lead to further development of the product for treating fibrosis such as Idiopathic Pulmonary Fibrosis and Liver Cirrhosis.

Read the entire article at:

http://www.baystreet.ca/viewarticle.aspx?id=409245

For more information about Idiopathic Pulmonary Fibrosis please visit our websitewww.ipftoday.com

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October 28 2013 – Ambrisentan (Letairis) stopped early in IPF trial (Annals Int Med)

Ambrisentan (Letairis) stopped early in IPF trial

A large phase III randomized trial testing Ambrisentan (Letairis) for early

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October 21 2013 – Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study

Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study

Original Text

Prof Ferran Morell MD a b Corresponding AuthorEmail Address, Ana Villar MD a b, Mar

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October 18 2013 – UW researchers to test novel therapy for idiopathic pulmonary fibrosis

Dear Colleagues:

I am very pleased to report that UW researchers have received a grant from the National Institutes of Health (NIH) to test a promising, novel surgical therapy for treating idiopathic pulmonary fibrosis (IPF). IPF is a chronic, progressive lung disease of unknown cause and increasing prevalence in the United States. An estimated 100,000 Americans die from IPF each year, typically within three to five years of diagnosis.

The disease is characterized by development of excess fibrous tissue in the lungs. Aside from lung transplantation, which only one percent of affected patients receive, there is no FDA-approved therapy. The grant brings new hope for slowing progression of a fatal disease through safe, minimally invasive surgery.

Read the entire article at:

http://engage.washington.edu/site/PageNavigator/UWMedicine/OnlineNews/OnlineNews_10_18_2013.html

For more information about Idiopathic Pulmonary Fibrosis please visit our websitewww.ipftoday.com

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October 13 2013 – Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice

Despite the established role of alveolar type II epithelial cells for the maintenance of pulmonary function, little is known about the deregulation of lipid composition in the pathogenesis of pulmonary fibrosis. The elongation of long-chain fatty acids family member 6 (Elovl6) is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids. Here we show that Elovl6 expression is significantly downregulated after an intratracheal instillation of bleomycin (BLM) and in human lung with idiopathic pulmonary fibrosis.

Read the entire article at:

http://www.nature.com/ncomms/2013/131011/ncomms3563/full/ncomms3563.html

For more information about Idiopathic Pulmonary Fibrosis please visit our websitewww.ipftoday.com

Posted in Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, IPF, Long Fibrose, Lung Cancer, Lungen Fibrose, Medical, Pulmonary Fibrosis, Uncategorized | Tagged , , , , , , , , , , , , , , , , | Leave a comment